Primary testicular lymphoma with central nervous system involvement.

Primary testicular lymphoma (PTL) is a rare, aggressive form of non-Hodgkin’s lymphoma (NHL) with a poor prognosis. The standard treatment strategy for cases of PTL with advanced stage at diagnosis, especially those with central nervous system (CNS) involvement, remains to be established. Here, we report the case of a 63-year-old Japanese man who developed PTL with CNS involvement, and was safely and effectively treated with CHASER (cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab). CHASER led to the improvement of the neurological symptoms, and no signs of lymphoma were detected by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), including in the cerebrospinal fluid. In addition, peripheral blood stem cell harvest was successfully completed after four courses of CHASER. The present case suggests the possibility of CHASER as a safe and effective induction therapy for advanced NHL with CNS involvement at diagnosis.